A human circulating immune cell landscape in aging and COVID-19.
Identifieur interne : 000984 ( Main/Exploration ); précédent : 000983; suivant : 000985A human circulating immune cell landscape in aging and COVID-19.
Auteurs : Yingfeng Zheng [République populaire de Chine] ; Xiuxing Liu [République populaire de Chine] ; Wenqing Le [République populaire de Chine] ; Lihui Xie [République populaire de Chine] ; He Li [République populaire de Chine] ; Wen Wen [République populaire de Chine] ; Si Wang [République populaire de Chine] ; Shuai Ma [République populaire de Chine] ; Zhaohao Huang [République populaire de Chine] ; Jinguo Ye [République populaire de Chine] ; Wen Shi [République populaire de Chine] ; Yanxia Ye [République populaire de Chine] ; Zunpeng Liu [République populaire de Chine] ; Moshi Song [République populaire de Chine] ; Weiqi Zhang [République populaire de Chine] ; Jing-Dong J. Han [République populaire de Chine] ; Juan Carlos Izpisua Belmonte [États-Unis] ; Chuanle Xiao [République populaire de Chine] ; Jing Qu [République populaire de Chine] ; Hongyang Wang [République populaire de Chine] ; Guang-Hui Liu [République populaire de Chine] ; Wenru Su [République populaire de Chine]Source :
- Protein & cell [ 1674-8018 ] ; 2020.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Analyse de profil d'expression de gènes (MeSH), Analyse de séquence d'ARN (MeSH), Analyse sur cellule unique (MeSH), Assemblage et désassemblage de la chromatine (MeSH), Betacoronavirus (MeSH), Cytokines (biosynthèse), Cytokines (génétique), Cytométrie en flux (méthodes), Humains (MeSH), Immunocompétence (génétique), Infections à coronavirus (immunologie), Inflammation (génétique), Inflammation (immunologie), Jeune adulte (MeSH), Lignage cellulaire (MeSH), Lymphocytes T CD4+ (métabolisme), Pandémies (MeSH), Pneumopathie virale (immunologie), Prédisposition aux maladies (MeSH), Réarrangement des gènes (MeSH), Régulation de l'expression des gènes au cours du développement (MeSH), Spectrométrie de masse (méthodes), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Système immunitaire (croissance et développement), Système immunitaire (cytologie), Système immunitaire (immunologie), Transcriptome (MeSH), Vieillissement (génétique), Vieillissement (immunologie).
- MESH :
- biosynthèse : Cytokines.
- croissance et développement : Système immunitaire.
- cytologie : Système immunitaire.
- génétique : Cytokines, Immunocompétence, Inflammation, Vieillissement.
- immunologie : Infections à coronavirus, Inflammation, Pneumopathie virale, Système immunitaire, Vieillissement.
- métabolisme : Lymphocytes T CD4+.
- méthodes : Cytométrie en flux, Spectrométrie de masse.
- Adulte, Adulte d'âge moyen, Analyse de profil d'expression de gènes, Analyse de séquence d'ARN, Analyse sur cellule unique, Assemblage et désassemblage de la chromatine, Betacoronavirus, Humains, Jeune adulte, Lignage cellulaire, Pandémies, Prédisposition aux maladies, Réarrangement des gènes, Régulation de l'expression des gènes au cours du développement, Sujet âgé, Sujet âgé de 80 ans ou plus, Transcriptome.
English descriptors
- KwdEn :
- Adult (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Aging (genetics), Aging (immunology), Betacoronavirus (MeSH), CD4-Positive T-Lymphocytes (metabolism), Cell Lineage (MeSH), Chromatin Assembly and Disassembly (MeSH), Coronavirus Infections (immunology), Cytokine Release Syndrome (etiology), Cytokine Release Syndrome (immunology), Cytokines (biosynthesis), Cytokines (genetics), Disease Susceptibility (MeSH), Flow Cytometry (methods), Gene Expression Profiling (MeSH), Gene Expression Regulation, Developmental (MeSH), Gene Rearrangement (MeSH), Humans (MeSH), Immune System (cytology), Immune System (growth & development), Immune System (immunology), Immunocompetence (genetics), Inflammation (genetics), Inflammation (immunology), Mass Spectrometry (methods), Middle Aged (MeSH), Pandemics (MeSH), Pneumonia, Viral (immunology), Sequence Analysis, RNA (MeSH), Single-Cell Analysis (MeSH), Transcriptome (MeSH), Young Adult (MeSH).
- MESH :
- chemical , biosynthesis : Cytokines.
- cytology : Immune System.
- etiology : Cytokine Release Syndrome.
- genetics : Aging, Cytokines, Immunocompetence, Inflammation.
- growth & development : Immune System.
- immunology : Aging, Coronavirus Infections, Cytokine Release Syndrome, Immune System, Inflammation, Pneumonia, Viral.
- metabolism : CD4-Positive T-Lymphocytes.
- methods : Flow Cytometry, Mass Spectrometry.
- Adult, Aged, Aged, 80 and over, Betacoronavirus, Cell Lineage, Chromatin Assembly and Disassembly, Disease Susceptibility, Gene Expression Profiling, Gene Expression Regulation, Developmental, Gene Rearrangement, Humans, Middle Aged, Pandemics, Sequence Analysis, RNA, Single-Cell Analysis, Transcriptome, Young Adult.
Abstract
Age-associated changes in immune cells have been linked to an increased risk for infection. However, a global and detailed characterization of the changes that human circulating immune cells undergo with age is lacking. Here, we combined scRNA-seq, mass cytometry and scATAC-seq to compare immune cell types in peripheral blood collected from young and old subjects and patients with COVID-19. We found that the immune cell landscape was reprogrammed with age and was characterized by T cell polarization from naive and memory cells to effector, cytotoxic, exhausted and regulatory cells, along with increased late natural killer cells, age-associated B cells, inflammatory monocytes and age-associated dendritic cells. In addition, the expression of genes, which were implicated in coronavirus susceptibility, was upregulated in a cell subtype-specific manner with age. Notably, COVID-19 promoted age-induced immune cell polarization and gene expression related to inflammation and cellular senescence. Therefore, these findings suggest that a dysregulated immune system and increased gene expression associated with SARS-CoV-2 susceptibility may at least partially account for COVID-19 vulnerability in the elderly.
DOI: 10.1007/s13238-020-00762-2
PubMed: 32780218
PubMed Central: PMC7417788
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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<author><name sortKey="Ye, Yanxia" sort="Ye, Yanxia" uniqKey="Ye Y" first="Yanxia" last="Ye">Yanxia Ye</name>
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<affiliation wicri:level="1"><nlm:affiliation>University of Chinese Academy of Sciences, Beijing, 100049, China.</nlm:affiliation>
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<author><name sortKey="Song, Moshi" sort="Song, Moshi" uniqKey="Song M" first="Moshi" last="Song">Moshi Song</name>
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<country xml:lang="fr">République populaire de Chine</country>
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<affiliation wicri:level="1"><nlm:affiliation>University of Chinese Academy of Sciences, Beijing, 100049, China.</nlm:affiliation>
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<author><name sortKey="Zhang, Weiqi" sort="Zhang, Weiqi" uniqKey="Zhang W" first="Weiqi" last="Zhang">Weiqi Zhang</name>
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<affiliation wicri:level="1"><nlm:affiliation>University of Chinese Academy of Sciences, Beijing, 100049, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
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<affiliation wicri:level="1"><nlm:affiliation>CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:affiliation>China National Center for Bioinformation, Beijing, 100101, China.</nlm:affiliation>
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<wicri:regionArea>China National Center for Bioinformation, Beijing, 100101</wicri:regionArea>
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<author><name sortKey="Han, Jing Dong J" sort="Han, Jing Dong J" uniqKey="Han J" first="Jing-Dong J" last="Han">Jing-Dong J. Han</name>
<affiliation wicri:level="4"><nlm:affiliation>Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Center for Quantitative Biology (CQB), Peking University, Beijing, 100871, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Center for Quantitative Biology (CQB), Peking University, Beijing, 100871</wicri:regionArea>
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<author><name sortKey="Belmonte, Juan Carlos Izpisua" sort="Belmonte, Juan Carlos Izpisua" uniqKey="Belmonte J" first="Juan Carlos Izpisua" last="Belmonte">Juan Carlos Izpisua Belmonte</name>
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<author><name sortKey="Xiao, Chuanle" sort="Xiao, Chuanle" uniqKey="Xiao C" first="Chuanle" last="Xiao">Chuanle Xiao</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060</wicri:regionArea>
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<author><name sortKey="Qu, Jing" sort="Qu, Jing" uniqKey="Qu J" first="Jing" last="Qu">Jing Qu</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. qujing@ioz.ac.cn.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101</wicri:regionArea>
<wicri:noRegion>100101</wicri:noRegion>
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<affiliation wicri:level="1"><nlm:affiliation>Institute for Stem Cell and Regeneration, CAS, Beijing, 100101, China. qujing@ioz.ac.cn.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute for Stem Cell and Regeneration, CAS, Beijing, 100101</wicri:regionArea>
<wicri:noRegion>100101</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>University of Chinese Academy of Sciences, Beijing, 100049, China. qujing@ioz.ac.cn.</nlm:affiliation>
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<author><name sortKey="Wang, Hongyang" sort="Wang, Hongyang" uniqKey="Wang H" first="Hongyang" last="Wang">Hongyang Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>National Center for Liver Cancer, Second Military Medical University, Shanghai, 200433, China. hywangk@vip.sina.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>National Center for Liver Cancer, Second Military Medical University, Shanghai, 200433</wicri:regionArea>
<wicri:noRegion>200433</wicri:noRegion>
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<author><name sortKey="Liu, Guang Hui" sort="Liu, Guang Hui" uniqKey="Liu G" first="Guang-Hui" last="Liu">Guang-Hui Liu</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. ghliu@ioz.ac.cn.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101</wicri:regionArea>
<wicri:noRegion>100101</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Institute for Stem Cell and Regeneration, CAS, Beijing, 100101, China. ghliu@ioz.ac.cn.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute for Stem Cell and Regeneration, CAS, Beijing, 100101</wicri:regionArea>
<wicri:noRegion>100101</wicri:noRegion>
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<affiliation wicri:level="1"><nlm:affiliation>University of Chinese Academy of Sciences, Beijing, 100049, China. ghliu@ioz.ac.cn.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>University of Chinese Academy of Sciences, Beijing, 100049</wicri:regionArea>
<wicri:noRegion>100049</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, 100053, China. ghliu@ioz.ac.cn.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, 100053</wicri:regionArea>
<wicri:noRegion>100053</wicri:noRegion>
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<author><name sortKey="Su, Wenru" sort="Su, Wenru" uniqKey="Su W" first="Wenru" last="Su">Wenru Su</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China. suwenru@gzzoc.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060</wicri:regionArea>
<wicri:noRegion>510060</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2020">2020</date>
<idno type="RBID">pubmed:32780218</idno>
<idno type="pmid">32780218</idno>
<idno type="doi">10.1007/s13238-020-00762-2</idno>
<idno type="pmc">PMC7417788</idno>
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<idno type="wicri:Area/Main/Exploration">000717</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">A human circulating immune cell landscape in aging and COVID-19.</title>
<author><name sortKey="Zheng, Yingfeng" sort="Zheng, Yingfeng" uniqKey="Zheng Y" first="Yingfeng" last="Zheng">Yingfeng Zheng</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060</wicri:regionArea>
<wicri:noRegion>510060</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Xiuxing" sort="Liu, Xiuxing" uniqKey="Liu X" first="Xiuxing" last="Liu">Xiuxing Liu</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060</wicri:regionArea>
<wicri:noRegion>510060</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Le, Wenqing" sort="Le, Wenqing" uniqKey="Le W" first="Wenqing" last="Le">Wenqing Le</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Critical Care, Wuhan Hankou Hospital, Wuhan, 430012, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Critical Care, Wuhan Hankou Hospital, Wuhan, 430012</wicri:regionArea>
<wicri:noRegion>430012</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xie, Lihui" sort="Xie, Lihui" uniqKey="Xie L" first="Lihui" last="Xie">Lihui Xie</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060</wicri:regionArea>
<wicri:noRegion>510060</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Li, He" sort="Li, He" uniqKey="Li H" first="He" last="Li">He Li</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060</wicri:regionArea>
<wicri:noRegion>510060</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wen, Wen" sort="Wen, Wen" uniqKey="Wen W" first="Wen" last="Wen">Wen Wen</name>
<affiliation wicri:level="1"><nlm:affiliation>National Center for Liver Cancer, Second Military Medical University, Shanghai, 200433, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>National Center for Liver Cancer, Second Military Medical University, Shanghai, 200433</wicri:regionArea>
<wicri:noRegion>200433</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Si" sort="Wang, Si" uniqKey="Wang S" first="Si" last="Wang">Si Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101</wicri:regionArea>
<wicri:noRegion>100101</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Institute for Stem Cell and Regeneration, CAS, Beijing, 100101, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute for Stem Cell and Regeneration, CAS, Beijing, 100101</wicri:regionArea>
<wicri:noRegion>100101</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>University of Chinese Academy of Sciences, Beijing, 100049, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>University of Chinese Academy of Sciences, Beijing, 100049</wicri:regionArea>
<wicri:noRegion>100049</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, 100053, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, 100053</wicri:regionArea>
<wicri:noRegion>100053</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ma, Shuai" sort="Ma, Shuai" uniqKey="Ma S" first="Shuai" last="Ma">Shuai Ma</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101</wicri:regionArea>
<wicri:noRegion>100101</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Institute for Stem Cell and Regeneration, CAS, Beijing, 100101, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute for Stem Cell and Regeneration, CAS, Beijing, 100101</wicri:regionArea>
<wicri:noRegion>100101</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>University of Chinese Academy of Sciences, Beijing, 100049, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>University of Chinese Academy of Sciences, Beijing, 100049</wicri:regionArea>
<wicri:noRegion>100049</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Huang, Zhaohao" sort="Huang, Zhaohao" uniqKey="Huang Z" first="Zhaohao" last="Huang">Zhaohao Huang</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060</wicri:regionArea>
<wicri:noRegion>510060</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ye, Jinguo" sort="Ye, Jinguo" uniqKey="Ye J" first="Jinguo" last="Ye">Jinguo Ye</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060</wicri:regionArea>
<wicri:noRegion>510060</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shi, Wen" sort="Shi, Wen" uniqKey="Shi W" first="Wen" last="Shi">Wen Shi</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060</wicri:regionArea>
<wicri:noRegion>510060</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ye, Yanxia" sort="Ye, Yanxia" uniqKey="Ye Y" first="Yanxia" last="Ye">Yanxia Ye</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101</wicri:regionArea>
<wicri:noRegion>100101</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Zunpeng" sort="Liu, Zunpeng" uniqKey="Liu Z" first="Zunpeng" last="Liu">Zunpeng Liu</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101</wicri:regionArea>
<wicri:noRegion>100101</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>University of Chinese Academy of Sciences, Beijing, 100049, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>University of Chinese Academy of Sciences, Beijing, 100049</wicri:regionArea>
<wicri:noRegion>100049</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Song, Moshi" sort="Song, Moshi" uniqKey="Song M" first="Moshi" last="Song">Moshi Song</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101</wicri:regionArea>
<wicri:noRegion>100101</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Institute for Stem Cell and Regeneration, CAS, Beijing, 100101, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute for Stem Cell and Regeneration, CAS, Beijing, 100101</wicri:regionArea>
<wicri:noRegion>100101</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>University of Chinese Academy of Sciences, Beijing, 100049, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>University of Chinese Academy of Sciences, Beijing, 100049</wicri:regionArea>
<wicri:noRegion>100049</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhang, Weiqi" sort="Zhang, Weiqi" uniqKey="Zhang W" first="Weiqi" last="Zhang">Weiqi Zhang</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute for Stem Cell and Regeneration, CAS, Beijing, 100101, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute for Stem Cell and Regeneration, CAS, Beijing, 100101</wicri:regionArea>
<wicri:noRegion>100101</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>University of Chinese Academy of Sciences, Beijing, 100049, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>University of Chinese Academy of Sciences, Beijing, 100049</wicri:regionArea>
<wicri:noRegion>100049</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101</wicri:regionArea>
<wicri:noRegion>100101</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>China National Center for Bioinformation, Beijing, 100101, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>China National Center for Bioinformation, Beijing, 100101</wicri:regionArea>
<wicri:noRegion>100101</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Han, Jing Dong J" sort="Han, Jing Dong J" uniqKey="Han J" first="Jing-Dong J" last="Han">Jing-Dong J. Han</name>
<affiliation wicri:level="4"><nlm:affiliation>Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Center for Quantitative Biology (CQB), Peking University, Beijing, 100871, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Center for Quantitative Biology (CQB), Peking University, Beijing, 100871</wicri:regionArea>
<orgName type="university">Université de Pékin</orgName>
<placeName><settlement type="city">Pékin</settlement>
<region type="capitale">Pékin</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Belmonte, Juan Carlos Izpisua" sort="Belmonte, Juan Carlos Izpisua" uniqKey="Belmonte J" first="Juan Carlos Izpisua" last="Belmonte">Juan Carlos Izpisua Belmonte</name>
<affiliation wicri:level="2"><nlm:affiliation>Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Xiao, Chuanle" sort="Xiao, Chuanle" uniqKey="Xiao C" first="Chuanle" last="Xiao">Chuanle Xiao</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060</wicri:regionArea>
<wicri:noRegion>510060</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Qu, Jing" sort="Qu, Jing" uniqKey="Qu J" first="Jing" last="Qu">Jing Qu</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. qujing@ioz.ac.cn.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101</wicri:regionArea>
<wicri:noRegion>100101</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Institute for Stem Cell and Regeneration, CAS, Beijing, 100101, China. qujing@ioz.ac.cn.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute for Stem Cell and Regeneration, CAS, Beijing, 100101</wicri:regionArea>
<wicri:noRegion>100101</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>University of Chinese Academy of Sciences, Beijing, 100049, China. qujing@ioz.ac.cn.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>University of Chinese Academy of Sciences, Beijing, 100049</wicri:regionArea>
<wicri:noRegion>100049</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Hongyang" sort="Wang, Hongyang" uniqKey="Wang H" first="Hongyang" last="Wang">Hongyang Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>National Center for Liver Cancer, Second Military Medical University, Shanghai, 200433, China. hywangk@vip.sina.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>National Center for Liver Cancer, Second Military Medical University, Shanghai, 200433</wicri:regionArea>
<wicri:noRegion>200433</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Guang Hui" sort="Liu, Guang Hui" uniqKey="Liu G" first="Guang-Hui" last="Liu">Guang-Hui Liu</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. ghliu@ioz.ac.cn.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101</wicri:regionArea>
<wicri:noRegion>100101</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Institute for Stem Cell and Regeneration, CAS, Beijing, 100101, China. ghliu@ioz.ac.cn.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute for Stem Cell and Regeneration, CAS, Beijing, 100101</wicri:regionArea>
<wicri:noRegion>100101</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>University of Chinese Academy of Sciences, Beijing, 100049, China. ghliu@ioz.ac.cn.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>University of Chinese Academy of Sciences, Beijing, 100049</wicri:regionArea>
<wicri:noRegion>100049</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, 100053, China. ghliu@ioz.ac.cn.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, 100053</wicri:regionArea>
<wicri:noRegion>100053</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Su, Wenru" sort="Su, Wenru" uniqKey="Su W" first="Wenru" last="Su">Wenru Su</name>
<affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China. suwenru@gzzoc.com.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060</wicri:regionArea>
<wicri:noRegion>510060</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Protein & cell</title>
<idno type="eISSN">1674-8018</idno>
<imprint><date when="2020" type="published">2020</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term>
<term>Aged (MeSH)</term>
<term>Aged, 80 and over (MeSH)</term>
<term>Aging (genetics)</term>
<term>Aging (immunology)</term>
<term>Betacoronavirus (MeSH)</term>
<term>CD4-Positive T-Lymphocytes (metabolism)</term>
<term>Cell Lineage (MeSH)</term>
<term>Chromatin Assembly and Disassembly (MeSH)</term>
<term>Coronavirus Infections (immunology)</term>
<term>Cytokine Release Syndrome (etiology)</term>
<term>Cytokine Release Syndrome (immunology)</term>
<term>Cytokines (biosynthesis)</term>
<term>Cytokines (genetics)</term>
<term>Disease Susceptibility (MeSH)</term>
<term>Flow Cytometry (methods)</term>
<term>Gene Expression Profiling (MeSH)</term>
<term>Gene Expression Regulation, Developmental (MeSH)</term>
<term>Gene Rearrangement (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Immune System (cytology)</term>
<term>Immune System (growth & development)</term>
<term>Immune System (immunology)</term>
<term>Immunocompetence (genetics)</term>
<term>Inflammation (genetics)</term>
<term>Inflammation (immunology)</term>
<term>Mass Spectrometry (methods)</term>
<term>Middle Aged (MeSH)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (immunology)</term>
<term>Sequence Analysis, RNA (MeSH)</term>
<term>Single-Cell Analysis (MeSH)</term>
<term>Transcriptome (MeSH)</term>
<term>Young Adult (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term>
<term>Adulte d'âge moyen (MeSH)</term>
<term>Analyse de profil d'expression de gènes (MeSH)</term>
<term>Analyse de séquence d'ARN (MeSH)</term>
<term>Analyse sur cellule unique (MeSH)</term>
<term>Assemblage et désassemblage de la chromatine (MeSH)</term>
<term>Betacoronavirus (MeSH)</term>
<term>Cytokines (biosynthèse)</term>
<term>Cytokines (génétique)</term>
<term>Cytométrie en flux (méthodes)</term>
<term>Humains (MeSH)</term>
<term>Immunocompétence (génétique)</term>
<term>Infections à coronavirus (immunologie)</term>
<term>Inflammation (génétique)</term>
<term>Inflammation (immunologie)</term>
<term>Jeune adulte (MeSH)</term>
<term>Lignage cellulaire (MeSH)</term>
<term>Lymphocytes T CD4+ (métabolisme)</term>
<term>Pandémies (MeSH)</term>
<term>Pneumopathie virale (immunologie)</term>
<term>Prédisposition aux maladies (MeSH)</term>
<term>Réarrangement des gènes (MeSH)</term>
<term>Régulation de l'expression des gènes au cours du développement (MeSH)</term>
<term>Spectrométrie de masse (méthodes)</term>
<term>Sujet âgé (MeSH)</term>
<term>Sujet âgé de 80 ans ou plus (MeSH)</term>
<term>Système immunitaire (croissance et développement)</term>
<term>Système immunitaire (cytologie)</term>
<term>Système immunitaire (immunologie)</term>
<term>Transcriptome (MeSH)</term>
<term>Vieillissement (génétique)</term>
<term>Vieillissement (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Cytokines</term>
</keywords>
<keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Cytokines</term>
</keywords>
<keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Système immunitaire</term>
</keywords>
<keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Système immunitaire</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Immune System</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cytokine Release Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Aging</term>
<term>Cytokines</term>
<term>Immunocompetence</term>
<term>Inflammation</term>
</keywords>
<keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Immune System</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Cytokines</term>
<term>Immunocompétence</term>
<term>Inflammation</term>
<term>Vieillissement</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Inflammation</term>
<term>Pneumopathie virale</term>
<term>Système immunitaire</term>
<term>Vieillissement</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Aging</term>
<term>Coronavirus Infections</term>
<term>Cytokine Release Syndrome</term>
<term>Immune System</term>
<term>Inflammation</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>CD4-Positive T-Lymphocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Flow Cytometry</term>
<term>Mass Spectrometry</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Lymphocytes T CD4+</term>
</keywords>
<keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Cytométrie en flux</term>
<term>Spectrométrie de masse</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Betacoronavirus</term>
<term>Cell Lineage</term>
<term>Chromatin Assembly and Disassembly</term>
<term>Disease Susceptibility</term>
<term>Gene Expression Profiling</term>
<term>Gene Expression Regulation, Developmental</term>
<term>Gene Rearrangement</term>
<term>Humans</term>
<term>Middle Aged</term>
<term>Pandemics</term>
<term>Sequence Analysis, RNA</term>
<term>Single-Cell Analysis</term>
<term>Transcriptome</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse de profil d'expression de gènes</term>
<term>Analyse de séquence d'ARN</term>
<term>Analyse sur cellule unique</term>
<term>Assemblage et désassemblage de la chromatine</term>
<term>Betacoronavirus</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Lignage cellulaire</term>
<term>Pandémies</term>
<term>Prédisposition aux maladies</term>
<term>Réarrangement des gènes</term>
<term>Régulation de l'expression des gènes au cours du développement</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Transcriptome</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Age-associated changes in immune cells have been linked to an increased risk for infection. However, a global and detailed characterization of the changes that human circulating immune cells undergo with age is lacking. Here, we combined scRNA-seq, mass cytometry and scATAC-seq to compare immune cell types in peripheral blood collected from young and old subjects and patients with COVID-19. We found that the immune cell landscape was reprogrammed with age and was characterized by T cell polarization from naive and memory cells to effector, cytotoxic, exhausted and regulatory cells, along with increased late natural killer cells, age-associated B cells, inflammatory monocytes and age-associated dendritic cells. In addition, the expression of genes, which were implicated in coronavirus susceptibility, was upregulated in a cell subtype-specific manner with age. Notably, COVID-19 promoted age-induced immune cell polarization and gene expression related to inflammation and cellular senescence. Therefore, these findings suggest that a dysregulated immune system and increased gene expression associated with SARS-CoV-2 susceptibility may at least partially account for COVID-19 vulnerability in the elderly.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32780218</PMID>
<DateCompleted><Year>2020</Year>
<Month>10</Month>
<Day>05</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>10</Month>
<Day>08</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1674-8018</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>11</Volume>
<Issue>10</Issue>
<PubDate><Year>2020</Year>
<Month>10</Month>
</PubDate>
</JournalIssue>
<Title>Protein & cell</Title>
<ISOAbbreviation>Protein Cell</ISOAbbreviation>
</Journal>
<ArticleTitle>A human circulating immune cell landscape in aging and COVID-19.</ArticleTitle>
<Pagination><MedlinePgn>740-770</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1007/s13238-020-00762-2</ELocationID>
<Abstract><AbstractText>Age-associated changes in immune cells have been linked to an increased risk for infection. However, a global and detailed characterization of the changes that human circulating immune cells undergo with age is lacking. Here, we combined scRNA-seq, mass cytometry and scATAC-seq to compare immune cell types in peripheral blood collected from young and old subjects and patients with COVID-19. We found that the immune cell landscape was reprogrammed with age and was characterized by T cell polarization from naive and memory cells to effector, cytotoxic, exhausted and regulatory cells, along with increased late natural killer cells, age-associated B cells, inflammatory monocytes and age-associated dendritic cells. In addition, the expression of genes, which were implicated in coronavirus susceptibility, was upregulated in a cell subtype-specific manner with age. Notably, COVID-19 promoted age-induced immune cell polarization and gene expression related to inflammation and cellular senescence. Therefore, these findings suggest that a dysregulated immune system and increased gene expression associated with SARS-CoV-2 susceptibility may at least partially account for COVID-19 vulnerability in the elderly.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zheng</LastName>
<ForeName>Yingfeng</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Xiuxing</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Le</LastName>
<ForeName>Wenqing</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Department of Critical Care, Wuhan Hankou Hospital, Wuhan, 430012, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xie</LastName>
<ForeName>Lihui</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>He</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wen</LastName>
<ForeName>Wen</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>National Center for Liver Cancer, Second Military Medical University, Shanghai, 200433, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Si</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute for Stem Cell and Regeneration, CAS, Beijing, 100101, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>University of Chinese Academy of Sciences, Beijing, 100049, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, 100053, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ma</LastName>
<ForeName>Shuai</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute for Stem Cell and Regeneration, CAS, Beijing, 100101, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>University of Chinese Academy of Sciences, Beijing, 100049, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Huang</LastName>
<ForeName>Zhaohao</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ye</LastName>
<ForeName>Jinguo</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shi</LastName>
<ForeName>Wen</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ye</LastName>
<ForeName>Yanxia</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Zunpeng</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>University of Chinese Academy of Sciences, Beijing, 100049, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Song</LastName>
<ForeName>Moshi</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute for Stem Cell and Regeneration, CAS, Beijing, 100101, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>University of Chinese Academy of Sciences, Beijing, 100049, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Weiqi</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Institute for Stem Cell and Regeneration, CAS, Beijing, 100101, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>University of Chinese Academy of Sciences, Beijing, 100049, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>China National Center for Bioinformation, Beijing, 100101, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Han</LastName>
<ForeName>Jing-Dong J</ForeName>
<Initials>JJ</Initials>
<AffiliationInfo><Affiliation>Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Center for Quantitative Biology (CQB), Peking University, Beijing, 100871, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Belmonte</LastName>
<ForeName>Juan Carlos Izpisua</ForeName>
<Initials>JCI</Initials>
<AffiliationInfo><Affiliation>Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xiao</LastName>
<ForeName>Chuanle</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Qu</LastName>
<ForeName>Jing</ForeName>
<Initials>J</Initials>
<Identifier Source="ORCID">http://orcid.org/0000-0002-3988-5067</Identifier>
<AffiliationInfo><Affiliation>State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. qujing@ioz.ac.cn.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute for Stem Cell and Regeneration, CAS, Beijing, 100101, China. qujing@ioz.ac.cn.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>University of Chinese Academy of Sciences, Beijing, 100049, China. qujing@ioz.ac.cn.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Hongyang</ForeName>
<Initials>H</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0002-4709-3334</Identifier>
<AffiliationInfo><Affiliation>National Center for Liver Cancer, Second Military Medical University, Shanghai, 200433, China. hywangk@vip.sina.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Guang-Hui</ForeName>
<Initials>GH</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0001-9289-8177</Identifier>
<AffiliationInfo><Affiliation>State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. ghliu@ioz.ac.cn.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute for Stem Cell and Regeneration, CAS, Beijing, 100101, China. ghliu@ioz.ac.cn.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>University of Chinese Academy of Sciences, Beijing, 100049, China. ghliu@ioz.ac.cn.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, 100053, China. ghliu@ioz.ac.cn.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Su</LastName>
<ForeName>Wenru</ForeName>
<Initials>W</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0002-0506-6362</Identifier>
<AffiliationInfo><Affiliation>State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China. suwenru@gzzoc.com.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
<PublicationType UI="D016454">Review</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>08</Month>
<Day>11</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Germany</Country>
<MedlineTA>Protein Cell</MedlineTA>
<NlmUniqueID>101532368</NlmUniqueID>
<ISSNLinking>1674-800X</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016207">Cytokines</NameOfSubstance>
</Chemical>
</ChemicalList>
<SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName>
<SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName>
</SupplMeshList>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Protein Cell. 2020 Oct;11(10):703-706</RefSource>
<PMID Version="1">32894404</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000375" MajorTopicYN="N">Aging</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="Y">Betacoronavirus</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015496" MajorTopicYN="N">CD4-Positive T-Lymphocytes</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019070" MajorTopicYN="N">Cell Lineage</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D042002" MajorTopicYN="N">Chromatin Assembly and Disassembly</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000080424" MajorTopicYN="N">Cytokine Release Syndrome</DescriptorName>
<QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName>
<QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004198" MajorTopicYN="N">Disease Susceptibility</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005434" MajorTopicYN="N">Flow Cytometry</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020869" MajorTopicYN="N">Gene Expression Profiling</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018507" MajorTopicYN="N">Gene Expression Regulation, Developmental</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015321" MajorTopicYN="N">Gene Rearrangement</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007107" MajorTopicYN="N">Immune System</DescriptorName>
<QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName>
<QualifierName UI="Q000254" MajorTopicYN="N">growth & development</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007121" MajorTopicYN="N">Immunocompetence</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007249" MajorTopicYN="N">Inflammation</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013058" MajorTopicYN="N">Mass Spectrometry</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="Y">Pandemics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017423" MajorTopicYN="N">Sequence Analysis, RNA</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D059010" MajorTopicYN="Y">Single-Cell Analysis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D059467" MajorTopicYN="N">Transcriptome</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">COVID-19</Keyword>
<Keyword MajorTopicYN="Y">aging</Keyword>
<Keyword MajorTopicYN="Y">blood</Keyword>
<Keyword MajorTopicYN="Y">immune cells</Keyword>
<Keyword MajorTopicYN="Y">single-cell sequencing</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year>
<Month>06</Month>
<Day>22</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>07</Month>
<Day>01</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>8</Month>
<Day>12</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>10</Month>
<Day>6</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>8</Month>
<Day>12</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">32780218</ArticleId>
<ArticleId IdType="doi">10.1007/s13238-020-00762-2</ArticleId>
<ArticleId IdType="pii">10.1007/s13238-020-00762-2</ArticleId>
<ArticleId IdType="pmc">PMC7417788</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>République populaire de Chine</li>
<li>États-Unis</li>
</country>
<region><li>Californie</li>
<li>Pékin</li>
</region>
<settlement><li>Pékin</li>
</settlement>
<orgName><li>Université de Pékin</li>
</orgName>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Zheng, Yingfeng" sort="Zheng, Yingfeng" uniqKey="Zheng Y" first="Yingfeng" last="Zheng">Yingfeng Zheng</name>
</noRegion>
<name sortKey="Han, Jing Dong J" sort="Han, Jing Dong J" uniqKey="Han J" first="Jing-Dong J" last="Han">Jing-Dong J. Han</name>
<name sortKey="Huang, Zhaohao" sort="Huang, Zhaohao" uniqKey="Huang Z" first="Zhaohao" last="Huang">Zhaohao Huang</name>
<name sortKey="Le, Wenqing" sort="Le, Wenqing" uniqKey="Le W" first="Wenqing" last="Le">Wenqing Le</name>
<name sortKey="Li, He" sort="Li, He" uniqKey="Li H" first="He" last="Li">He Li</name>
<name sortKey="Liu, Guang Hui" sort="Liu, Guang Hui" uniqKey="Liu G" first="Guang-Hui" last="Liu">Guang-Hui Liu</name>
<name sortKey="Liu, Guang Hui" sort="Liu, Guang Hui" uniqKey="Liu G" first="Guang-Hui" last="Liu">Guang-Hui Liu</name>
<name sortKey="Liu, Guang Hui" sort="Liu, Guang Hui" uniqKey="Liu G" first="Guang-Hui" last="Liu">Guang-Hui Liu</name>
<name sortKey="Liu, Guang Hui" sort="Liu, Guang Hui" uniqKey="Liu G" first="Guang-Hui" last="Liu">Guang-Hui Liu</name>
<name sortKey="Liu, Xiuxing" sort="Liu, Xiuxing" uniqKey="Liu X" first="Xiuxing" last="Liu">Xiuxing Liu</name>
<name sortKey="Liu, Zunpeng" sort="Liu, Zunpeng" uniqKey="Liu Z" first="Zunpeng" last="Liu">Zunpeng Liu</name>
<name sortKey="Liu, Zunpeng" sort="Liu, Zunpeng" uniqKey="Liu Z" first="Zunpeng" last="Liu">Zunpeng Liu</name>
<name sortKey="Ma, Shuai" sort="Ma, Shuai" uniqKey="Ma S" first="Shuai" last="Ma">Shuai Ma</name>
<name sortKey="Ma, Shuai" sort="Ma, Shuai" uniqKey="Ma S" first="Shuai" last="Ma">Shuai Ma</name>
<name sortKey="Ma, Shuai" sort="Ma, Shuai" uniqKey="Ma S" first="Shuai" last="Ma">Shuai Ma</name>
<name sortKey="Qu, Jing" sort="Qu, Jing" uniqKey="Qu J" first="Jing" last="Qu">Jing Qu</name>
<name sortKey="Qu, Jing" sort="Qu, Jing" uniqKey="Qu J" first="Jing" last="Qu">Jing Qu</name>
<name sortKey="Qu, Jing" sort="Qu, Jing" uniqKey="Qu J" first="Jing" last="Qu">Jing Qu</name>
<name sortKey="Shi, Wen" sort="Shi, Wen" uniqKey="Shi W" first="Wen" last="Shi">Wen Shi</name>
<name sortKey="Song, Moshi" sort="Song, Moshi" uniqKey="Song M" first="Moshi" last="Song">Moshi Song</name>
<name sortKey="Song, Moshi" sort="Song, Moshi" uniqKey="Song M" first="Moshi" last="Song">Moshi Song</name>
<name sortKey="Song, Moshi" sort="Song, Moshi" uniqKey="Song M" first="Moshi" last="Song">Moshi Song</name>
<name sortKey="Su, Wenru" sort="Su, Wenru" uniqKey="Su W" first="Wenru" last="Su">Wenru Su</name>
<name sortKey="Wang, Hongyang" sort="Wang, Hongyang" uniqKey="Wang H" first="Hongyang" last="Wang">Hongyang Wang</name>
<name sortKey="Wang, Si" sort="Wang, Si" uniqKey="Wang S" first="Si" last="Wang">Si Wang</name>
<name sortKey="Wang, Si" sort="Wang, Si" uniqKey="Wang S" first="Si" last="Wang">Si Wang</name>
<name sortKey="Wang, Si" sort="Wang, Si" uniqKey="Wang S" first="Si" last="Wang">Si Wang</name>
<name sortKey="Wang, Si" sort="Wang, Si" uniqKey="Wang S" first="Si" last="Wang">Si Wang</name>
<name sortKey="Wen, Wen" sort="Wen, Wen" uniqKey="Wen W" first="Wen" last="Wen">Wen Wen</name>
<name sortKey="Xiao, Chuanle" sort="Xiao, Chuanle" uniqKey="Xiao C" first="Chuanle" last="Xiao">Chuanle Xiao</name>
<name sortKey="Xie, Lihui" sort="Xie, Lihui" uniqKey="Xie L" first="Lihui" last="Xie">Lihui Xie</name>
<name sortKey="Ye, Jinguo" sort="Ye, Jinguo" uniqKey="Ye J" first="Jinguo" last="Ye">Jinguo Ye</name>
<name sortKey="Ye, Yanxia" sort="Ye, Yanxia" uniqKey="Ye Y" first="Yanxia" last="Ye">Yanxia Ye</name>
<name sortKey="Zhang, Weiqi" sort="Zhang, Weiqi" uniqKey="Zhang W" first="Weiqi" last="Zhang">Weiqi Zhang</name>
<name sortKey="Zhang, Weiqi" sort="Zhang, Weiqi" uniqKey="Zhang W" first="Weiqi" last="Zhang">Weiqi Zhang</name>
<name sortKey="Zhang, Weiqi" sort="Zhang, Weiqi" uniqKey="Zhang W" first="Weiqi" last="Zhang">Weiqi Zhang</name>
<name sortKey="Zhang, Weiqi" sort="Zhang, Weiqi" uniqKey="Zhang W" first="Weiqi" last="Zhang">Weiqi Zhang</name>
</country>
<country name="États-Unis"><region name="Californie"><name sortKey="Belmonte, Juan Carlos Izpisua" sort="Belmonte, Juan Carlos Izpisua" uniqKey="Belmonte J" first="Juan Carlos Izpisua" last="Belmonte">Juan Carlos Izpisua Belmonte</name>
</region>
</country>
</tree>
</affiliations>
</record>
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